The Dynamism of Intrinsically Disordered Proteins in Liquid-Liquid Phase Separation
نویسندگان
چکیده
منابع مشابه
Random-phase-approximation theory for sequence-dependent, biologically functional liquid-liquid phase separation of intrinsically disordered proteins
Intrinsically disordered proteins (IDPs) are typically low in nonpolar/hydrophobic but relatively high in polar, charged, and aromatic amino acid compositions. Some IDPs undergo liquid-liquid phase separation in the aqueous milieu of the living cell. The resulting phase with enhanced IDP concentration can function as a major component of membraneless organelles that, by creating their own IDP-r...
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Département de Biochimie, Université de Montréal, C.P. 6128, Succursale centre-ville, 9 Montréal, Québec, H3C 3J7, Canada. 10 Department of Bioengineering, McGill University, Montreal, Quebec, H3A0C3, Canada. 11 Ernest Rutherford Physics Building, 3600 rue University, McGill University, Montreal, Québec, 12 H3A2T8 13 Department of Biomedical Engineering and Center for Biological Systems Enginee...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2020
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2019.11.503